The ApoB GuideThe count behind your cholesterol
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What is my ApoB to ApoA1 ratio?

ApoB counts the particles that build plaque. ApoA1 is the main protein on HDL. Put the two side by side.

Showing an example. Type your own two numbers.

Your ApoB goal

0.80ApoB 112 over ApoA1 140 (1.12 over 1.40 g/L)

Move ApoB first

Move ApoB first. It's the half with a goal and the half trials can move. Your ApoB of 112 is at or over 90.

No US guideline sets a goal for this ratio.

3.25 timesIn 52 countries, people in the top fifth of the ratio had 3.25 times the odds of a heart attack of people in the bottom fifth (INTERHEART, Yusuf 2004).
54% against 37%In the lipid paper, the ratio explained more of the heart attacks than the cholesterol ratios did: 54% against 37% for LDL to HDL (INTERHEART, McQueen 2008).

What your ratio means

  1. No US guideline sets a goal for it, so the tool doesn't give one.
  2. Higher means more risk. In INTERHEART, people in the top fifth of the ratio had 3.25 times the odds of a heart attack of those in the bottom fifth.
  3. If your ApoB is over its goal, move ApoB first. It's the half with a goal, and the half that food and medicine trials can move.
  4. If your ApoB is at goal, ApoA1 is the main protein on HDL. Walking, cycling or swimming raised HDL a little in trials.

How it works

The ratio is ApoB divided by ApoA1, both in the same unit. Each box guesses its own unit from its size, so a number under 5 is taken as g/L. No US guideline sets a goal for the ratio, so the tool shows no bands. It says which half to look at: ApoB has a goal, and trials can move it.

In INTERHEART, 15,152 people with a first heart attack and 14,820 without in 52 countries, people in the top fifth of the ratio had 3.25 times the odds of a heart attack of those in the bottom fifth. The lipid paper from the same study found the ratio explained 54% of the heart attacks, against 37% for LDL to HDL.

4 sources
  1. Yusuf S and others, the INTERHEART study of heart attack risk factors in 52 countries, The Lancet, 2004pubmed.ncbi.nlm.nih.gov
  2. McQueen MJ and others, lipids and apolipoproteins in the INTERHEART study, The Lancet, 2008pubmed.ncbi.nlm.nih.gov
  3. Blumenthal RS, Morris PB, Gaudino M and others, 2026 ACC/AHA guideline on the management of dyslipidemia, JACC, 2026doi.org
  4. Soffer DE, Marston NA, Maki KC and others, Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: an Expert Clinical Consensus from the National Lipid Association, Journal of Clinical Lipidology, 2024pmc.ncbi.nlm.nih.gov

More tools

Test your ApoB at home with the Gyroscope blood panel, and Gyroscope One reads every result against what you ate and how you trained. Open Gyroscope

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